StatisticsÜyeler: 302
Haberler: 287
Bağlantılar: 0
Ziyaretçiler: 452240
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Drug discovery and development P118 : Determination of the ability of a recombinant protein to vaccinate against Leishmania mexicana
Basma Doro, Al-Fateh University, Faculty of pharmacy P119 A novel prodrug approach to combination therapy in the treatment of cardiovascular disease
Nisha Perez, Ironwood Pharmaceuticals; Peter Germano, Ironwood Pharmaceuticals; Shanelle Ko, Ironwood Pharmaceuticals; Wayne Schrairer, Ironwood Pharmaceuticals; Timothy C. Barden, Ironwood Pharmaceuticals; Brian M. Cali, Ironwood Pharmaceuticals; Jeffrey Segal, Ironwood Pharmaceuticals; Robert Busby, Ironwood Pharmaceuticals P120 Antioxidant Activity of Some Amide Derivatives of Diclofenac as Prodrugs
Tunca Gul Altuntas, Ankara University; Tulay Coban, Ankara University; Fatma Sener, Social Security Institution P121 Does Lipid Environment Modulate Drug Efflux Activity Of ABC Transporters?
Peter Meszaros, University of Groningen P122 Drug Development for Pediatric Population in Japan
Junko Komura, Pharmaceuticals & Medical Devices Agency P123 Effective MicroPET Imaging of Brain 5-HT1A Receptors in Rat with 18F-MEFWAY by Suppression of Radioligand Defluorination
Jae Yong Choi, Department of Pharmacology, Brain Research Institute, BK 21 Project for Medical Science, Yonsei University College of Medicine; Chul Hoon Kim, Department of Pharmacology, Brain Research Institute, BK 21 Project for Medical Science, Yonsei University College of Medicine; Byoung-Soo Kim, Korea Institute of Radiological and Medical Science; Eun Jung Kim, Korea Institute of Radiological and Medical Science; Jung Young Kim, Korea Institute of Radiological and Medical Science; Tae Hyun Choi, Korea Institute of Radiological and Medical Science; Young Hoon Ryu, Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospita P124 Identification of novel anti-androgens that target the BF3 site of the androgen receptor
Nathan Lack, Vancouver Prostate Centre; Peyman Tavassoli, Vancouver Prostate Centre; Peter Axerio, Vancouver Prostate Centre; Eric LeBlanc, Vancouver Prostate Centre; Emma Guns, Vancouver Prostate Centre; Artem Cherkasov, Vancouver Prostate Centre; Paul Rennie, Vancouver Prostate Centre P125 In vitro Reactivity and Metabolism of Irreversible Tyrosine Kinase Inhibitors
Chitra Mani, Pharmacyclics; Erik Verner, Pharmacyclics; Wei Chen, Pharmacyclics; David Loury, Pharmacyclics P126 Innovative Strategy for MIST using LC/RI/MS and nanoLC-MS to quantify the comprehensive metabolites
Zenzaburo Tozuka, Sekisui Medical Co., Ltd; Shinsuke Aoyama, Sekisui Medical Co., Ltd; Kohei Nozawa, Sekisui Medical Co., Ltd; Yasuhisa Adachi, Sekisui Medical Co., Ltd; Shin-ichi Ninomiya, Sekisui Medical Co., Ltd P127 Mass Balance Studies using LC-MS with Integrated UV Detection
Carmai Seto, AB Sciex; Takeo Sakuma, AB Sciex P129 Microcrystals prepared by in situ micronization: pharmacokinetic studies in rats
Roya Talari, Food and Drug Laboratories Research Center; Jaleh Varshosaz, Pharmacy Faculty, Isfahan University of Medical Sciences; Abolfazl Mostafavi, Pharmacy Faculty, Isfahan University of Medical Sciences; Ali Nokhodchi, Medway School of Pharmacy, The Universities of Kent and Greenwich P130 New Prodrugs of the Antiprotozoal Drug Pentamidine
Joscha Kotthaus, Christian-Albrechts-University; Björn Cohrs, Christian-Albrechts-University; Jürke Kotthaus, Christian-Albrechts-University; Dennis Schade, Christian-Albrechts-University; Helen Hungeling, Christian-Albrechts-University; Bernd Clement, Christian-Albrechts-University P131 Novel PET radiotracers for serotonin 5-HT1A P132 Novel reduction mechanism of Azo Pro-Drugs into anti-Inflammatory Arylamines by Azoreductases from Pseudomonas Aeruginosa
Laurieri Nicola, University of Oxford; Ryan Ali, University of Oxford; Isaac Westwood, University of Oxford; Chan-Ju Wang, University of Oxford; Ed Lowe, University of Oxford; Edith Sim, Univ of Oxford P133 Optimisation of Isoenzyme-Specific Reagents: Organic Synthesis and Biological Characterisation of Naphthoquinones as Selective Inhibitors of Human n-Acetyltransferase 1 (hnat1) and Mouse nat2 (mnat2)
Nicola Laurieri, Univ of Oxford; Cyrille Thinnes, Univ of Oxford; Isaac Westwood, Univ of Oxford; Ballester Pedro, Univ of Oxford; Peter Seden, Univ of Oxford; Stephen G. Davies, Univ of Oxford; Angela Russell, Univ of Oxford; Edith Sim, Univ of Oxford P134 Pharmacokinetics, distribution, metabolism, excretion and mass balance of radioactivity in rats following a single subcutaneous bolus injection of [35S]-ISIS 388626
Richard Harrison, Huntingdon Life Sciences; Colin Webber, Huntingdon Life Sciences; Rosie Yu, Isis Pharmaceuticals Inc; Richard Geary, Isis Pharmaceuticals Inc P135 PhD STUDENT el mrabet fatima zahra
el Mrabet fatima Zahra, Ibn tofail university, faculty of sciences; Ali Ouichou, Ibn tofail university, faculty of sciences; Abdehalim Mesfioui, Ibn tofail university, faculty of sciences P136 Preclinical Pharmacokinetic Assessment of GDC-0152, a Selective Antagonist of the Inhibitor of Apoptosis (IAP) Proteins
Hank La, Genentech; Jason S. Halladay, Genentech; Young Shin, Genentech; Susan Wong, Genentech; Emile Plise, Genentech; O. Helen Chan, Genentech; John Flygare, Genentech; Wayne Fairbrother, Genentech; Harvey Wong, Genentech P137 Preparation and Characterization of Clarithromycin Nanoparticles by Antisolvent Precipitation
Mansour Mansouri, Islamic Azad University, Shahreza Branch; Hamid Reza Pouretedal, Malek-e-ashtar University of Technology,Shahin-shahr; Mohammad Ali Hassan Ali, Islamic Azad University, Shahreza Branch P138 Preparation and Characterization of Erythromycin Ethylsuccinate Nanoparticles by Solvent/Anti-solvent Precipitation
Mohammad Ali Hassan Ali, Islamic Azad University, Shahreza Branch; Hamid Reza Pouretedal, Malek-e-ashtar University of Technology,Shahin-shahr; Mansour Mansouri, Islamic Azad University, Shahreza Branch P139 Structural Studies on the Mycobacterial Arylamine N-Acetyltransferases
Areej M. Abuhammad, Univ of Oxford; Edward D. Lowe, Univ of Oxford; Elizabeth Fullam, Univ of Oxford; Martin Noble, Univ of Oxford; Judith Schweichler, Univ of Oxford; Elspeth F. Garman, Univ of Oxford; Edith Sim, Univ of Oxford P141 Understanding retention of inhaled therapies in the lung
Sebastien Ronseaux, Novartis Horsham Research Centre; Ruth Lock, Novartis Horsham Research Centre; Bindi Sohal, Novartis Horsham Research Centre P142 Veliparib (ABT-888): a Novel, Potent PARP Inhibitor with Favorable ADME Properties
Richard Voorman, Abbott Laboratories; Xiaofeng Li, Abbott Laboratories; Alexander Shoemaker, Abbott Laboratories; Thomas Penning, Abbott Laboratories; Vincent Giranda, Abbott Laboratories; Juergen Delzer, Abbott Laboratories; Sonia de Morais, Abbott Laboratories; Yanbin Lao, Abbott Laboratories |
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Hepatocytes P238 Comparison of the effects of the Clofibrate and its siliconized analogue in freshly isolated rat hepatocytes
Mohammad A. Eghbal, Tabriz University of Medical Sciences; M. Ziaee, Tabriz University of Medical Sciences; AR Garjani, Tabriz University of Medical Sciences; H. Hamzeiy, Tabriz University of Medical Sciences; N. Saeedi Kozehkonani, Tabriz University of Medical Sciences; M. Bolourtchian, Chemistry and chemical engineering Research center of Iran,; M. Ghaffarzadeh, Chemistry and chemical engineering Research center of Iran,; M. Ahmadi, Chemistry and chemical engineering Research center of Iran, P237 Characterization of NTCP, OATP and OCT Function in Human Cryopreserved Hepatocytes in Suspension
Tom De Bruyn, Katholieke Universiteit Leuven; Zhi-Wei Ye, Katholieke Universiteit Leuven; Jasminder Sahi, Life Technologies; Patrick Augustijns, Katholieke Universiteit Leuven; Pieter Annaert, Katholieke Universiteit Leuven P241 Human Hepatocyte Cultures Allow Repeated Application of Drugs Resulting in Repeatable Effects On Hepatocellular Metabolism
Anett Ullrich, PRIMACYT Cell Culture Technology GmbH; Maciej Patrzyk, University of Greifswald; Dagmar Braun, Cheplapharm Arzneimittel GmbH; Beatrice Grossjohann, Riemser Arzneimittel AG; Dieter Runge, PRIMACYT Cell Culture Technology GmbH P242 Modulation of Antioxidant and Xenobiotic-Metabolising Enzymes in Primary Rat Hepatocytes by Glucosinolates
Margherita La Marca, Institute of Agricultural Biotechnology, CNR, via Moruzzi 1, 56100 Pisa, Italy; Pascale Beffy, Institute of Clinical Physiology, CNR, via Moruzzi 1, 56100 Pisa, Italy; Pier Giovanni Gervasi, Institute of Clinical Physiology, CNR, via Moruzzi 1, 56100 Pisa, Italy; Renato Iori, Research Center for Industrial Crops, Agricultural Research Council (CRA-CIN), Via di Corticella, 133, 40129 Bologna, Italy; Vincenzo Longo, Institute of Agricultural Biotechnology, CNR, via Moruzzi 1, 56100 Pisa, Italy P243 Plated human cryo-hepatocytes for metabolic stability assay
Haiyan Xia, BD Biosciences; Kirsten Cooper, BD Biosciences; Charles L. Crespi, BD Biosciences; Chris Patten, BD Biosciences; Rongjun Zuo, BD Biosciences P239 Development and Validation of a Novel Post-Thaw Recovery Media for Human Cryopreseved Hepatocytes
Jie Wang, BD Biosciences; Rongjun Zuo, BD Biosciences; Haiyan Xia, BD Biosciences; Sweta N. Parikh, BD Biosciences; Mercyanne Andes, BD Biosciences; Charles L. Crespi, BD Biosciences; Christopher J. Patten, BD Biosciences P244 Primary Human Hepatocytes Cultured in a 3D Bioreactor Maintain Cytochrome P450 Activity up to 3 Weeks
Malin Darnell, Clinical Pharmacology and DMPK; Thomas Schreiter, Charité Universitätsmedizin Berlin; Therese Söderdahl, Global Safety Assessment; Daniel Knobeloch, Charité Universitätsmedizin Berlin; Andreas K.N. Nüssler, TU Munich, MRI; Birgitta Dillner, Global Safety Assessment; Anna-Lena Berg, Global Safety Assessment; Jörg C. Gerlach, McGowan Institute for Regenerative Medicine, University of Pittsburgh, PA, USA; Katrin Zeilinger, Charité Universitätsmedizin Berlin; Tommy B. Andersson, Clinical Pharmacology and DMPK P245 Real Time PCR Analysis of Selected Oxidant/Antioxidant and Apoptotic Genes in D-Galactosamine-Lipopolysaccharide Hepatotoxicity in Rat
Natasa Lekic, Charles University in Prague, First Faculty of Medicine; Dalibor Cerny, Charles University in Prague, First Faculty of Medicine; Hassan Farghali, Charles University in Prague, First Faculty of Medicine P246 Resveratrol Decreases Ethanol-Induced Oxidative STRESS IN Rat Liver
Yesim A. Gocmen, Bozok University, Medical Faculty; Saadet Gumuslu, Akdeniz University, Medical Faculty P247 The effect of multiple cryopreservation cycles on drug-metabolizing enzymes in human hepatocytes
Kevin Lyon, XenoTech, LLC; Chad Pope, XenoTech, LLC; Melissa Ostermann, XenoTech, LLC; Maciej Czerwinski, XenoTech, LLC; Andrew Parkinson, XenoTech, LLC P240 Evaluation of Cryopreserved, Differentiated HepaRG Cells for the Simultaneous Determination of CYP450 Induction and Metabolism
Robert Annand, Apredica; Mary Jacewicz, Apredica; Christophe Chesné, Biopredic international; David Steen, Biopredic international; Katherine Tsaioun, Apredica P236 A Medium-throughput In Vitro System Incorporating Hepatocyte Sandwich Cultures And High Resolution Mass Spectrometry For Evaluating Metabolism And Biliary Clearance
Mary Grubb, Bristol-Myers Squibb Co; Jonathan Josephs, Bristol-Myers Squibb Co |
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Herb-Drug Interactions P266 Protective Effects of Globularia alypum Against Doxorubicin induced Cardiotoxicity
Nacira Aly Abidli, Mentouri University Constantine Faculty of science of nature and life ALGERIA; Wahiba Karaali, Mentouri University Constantine Faculty of science of nature and life ALGERIA P263 Local administration of medicinal plants in treating neurogastroenetrology & motility disorders: results from a cross-sectional study in Khulna district of Bangladesh
Md. Ariful Haque Mollik, Peoples Integrated Alliance P264 Mechanistic study on the metabolism inhibition of Oseltamivir by herbal components
Xiaoan Wang, School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong; Siukwan Wo, School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong; Zhong Zuo, School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong P265 Mechanistic understanding of the effects of 6 schisandrins on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus
Hui-chang Bi, Sun Yat-sen University; Xiao-ling Qin, Sun Yat-sen University; Xiao Chen, Sun Yat-sen University; Min Huang*, Sun Yat-sen University P261 Differential Effects of Cyclamen Extract on P450 Gene Expression
Sevki Arslan, Pamukkale University, Faculty of Arts & Sciences; Ozden Ozgun, Pamukkale University; Alaattin Sen, Pamukkale University P262 Effect of Naringenin on Metabolic Activity of Cytochrome P450 1a2 and 3a in BCG - Immune Liver Injury in Mice
Guo-Liang Zhang, Basic Medical School, Beijing University; Tao-Yuan Li, Basic Medical School, Beijing University; Xin Wang, Basic Medical School, Beijing University; Shu-Mei Wang, Basic Medical School, Beijing University; Dan Li, Basic Medical School, Beijing University; Xuan Zhao, Basic Medical School, Beijing University P260 Deoxyschizandrin improved the absorption of P-glycosprotein (P-gp) Substrate Drugs in Human Intestinal Caco-2 Cells
Ying Hu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Hui Xin Liu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Na Li, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Ling Yang, Dalian Institute of Chemical Physics, Chinese Academy of Sciences P259 Can silymarin prevent cardio and hepatotoxicity induced with doxorubicin?
Nebojsa Stilinovic, Faculty of Medicine Novi Sad; Roberto Sederino, Faculty of Medicine Novi Sad; Aleksandar Raskovic, Faculty of Medicine Novi Sad; Sasa Vukmirovic, Faculty of Medicine Novi Sad; Milica Paut, Faculty of Medicine Novi Sad |
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Metal Toxicity P367 Oral administration of lead induced hepatic and renal damage in wistar rats
Missoun Fatiha IV, UNIVERSITY OF MOSTAGANEM; Slimani Miloud, UNIVERSITY OF ORAN P366 Dose-dependant effect of chronic contamination to depleted uranium on xenobiotic metabolizing enzymes in rat
Yann Gueguen, IRSN; Caroline Rouas, IRSN; Audrey Monin, IRSN; Stéphane Grison, IRSN; Patrick Gourmelon, IRSN; Isabelle Dublineau, IRSN P365 Chromium Levels in Pulmonary Tissues from Lung Cancer and Control Subjects
Sevtap Gülgösteren, Atatürk Chest Diseases and Chest Surgery Education and Research Hospital; Görkem Mergen, Institute of Forensic Medicine, Ankara University; Mahmut Gülgösteren, Atatürk Chest Diseases and Chest Surgery Education and Research Hospital; H.Esra Özaydın, Atatürk Chest Diseases and Chest Surgery Education and Research Hospital; Vugar Aliyev, Institute of Forensic Medicine, Ankara University; Tülin Söylemezoğlu, Institute of Forensic Medicine, Ankara University; Cebrail Şimşek, Atatürk Chest Diseases and Chest Surgery Education and Research Hospital P369 The effect of various metals on polyphenol oxidase and peroxidase activities from goosefeet plant (Chenopodium anthelminthicum)
Gulnur Arabaci, Sakarya University; Ayse Usluoglu, Sakarya University |
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Metabolism P330 An Open-Label Study to Assess the Mass Balance and Metabolic Disposition of an Orally Administered Single Dose of 14C-Labeled Neratinib, an Irreversible pan-ErbB inhibitor, in Healthy Subjects
Richat Abbas-Borhan, Pfizer Inc.; Inder Chaudhary, Pfizer Inc.; Joel Kantrowitz, Pfizer Inc.; Bruce A. Hug, Pfizer Inc.; Cathie Leister, Pfizer Inc.; Jaime Burns, Pfizer Inc.; Daryl Sonnichsen, Pfizer Inc. P350 Mass Balance, Metabolic Disposition, Metabolite Characterization, and Pharmacokinetics of Oral 14C-Labeled Bosutinib in Healthy Subjects
Richat Abbas-Borhan, Pfizer Inc.; Inder Chaudhary, Pfizer Inc.; Bruce A. Hug, Pfizer Inc.; Cathie Leister, Pfizer Inc.; Jaime Burns, Pfizer Inc.; Sarvesh Vashishtha, Pfizer Inc.; John C.L. Erve, Pfizer Inc.; Daryl Sonnichsen, Pfizer Inc. P337 Compatative in Vitro Metabolism of A Benzylamine Containing Test Drug Using Human, Monkey, Rat, and Dog Plasma – Investigation of Amine Oxidase Involvement in Drug's Metabolism
Heasook Kim-Kang, XenoBiotic Laboratories, Inc.; Zheming Gu, XenoBiotic Laboratories, Inc. P341 Excretion and Metabolism of Forsythiaside in Rats
Qi Chang, Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College; Geng-Nan Wang, Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College; Yong-Hong Liao, Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College; Lei Zhang, Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College; Qian Wang, Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College; Bin-Xin Xiao, Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College P359 Reactive metabolites of thiophenic compounds: A new trapping method for thiophene sulfoxides
Patrick M. Dansette, Université Paris Descartes; Stéphanie Thébault, Université Paris Descartes; Lucie Durand-Gasselin, Université Paris Descartes; Gildas Bertho, Université Paris Descartes; Daniel Mansuy, Université Paris Descartes P357 Proportionality Assessment of Metabolites from Microdose to High Dose in Rats Using LC-MS
Jinsong Ni, Allergan; Hui Ouyang, Allergan; Carmai Seto, AB Sciex; Takeo Sakuma, AB Sciex; Robert Ellis, AB Sciex; Josh Rowe, Allergan; Andrew Acheampong, Allergan; Devin Welty, Allergan; Gabriella Szekely-Klepser, Allergan P349 Mass Balance and Metabolism of the Taxane Analog [14C]BMS-275183 Following Oral Administration to Humans
S. Nilgün Çömezoglu, Bristol-Myers Squibb; Van T. Ly, Bristol-Myers Squibb; Ihoezo V. Ekhato, Bristol-Myers Squibb; Jinping Gan, Bristol-Myers Squibb; Leila Alland, Bristol-Myers Squibb; W. Griff Humphreys, Bristol-Myers Squibb P354 Oxidative ipso-substitution of 2,4-difluoro-benzyl-phthalazines - Identification of a rare stable quinone methide and subsequent glutathione conjugate
Mithat Gunduz, Novartis; Upendra Argikar, Novartis; Franco Lombardo, Novartis; Shawn Harriman, Novartis P346 Influence of Fluorine Substitution at the C-3 Position on Oxidative Metabolism of N-Ethylpiperidine Analogs
Bianca M. Liederer, Genentech, Inc.; Vikki Dinkel, Array BioPharma, Inc.; John Gaudino, Array BioPharma, Inc.; Sashi Gopaul, Genentech, Inc.; Hoa Le, Genentech, Inc.; Xingrong Liu, Genentech, Inc.; Dan Sutherlin, Genentech, Inc.; Susan Wong, Genentech, Inc.; Cyrus Khojasteh, Genentech, Inc. P347 Investigation of Metabolism in Mice, Rats, Monkeys, Dogs and Humans of a Novel Met Kinase Inhibitor for Species Selection for Preclinical Toxicology Studies
Bianca M. Liederer, Genentech, Inc.; Matthew Baumgardner, Genentech, Inc.; Brian Dean, Genentech, Inc.; Vikki Dinkel, Array BioPharma, Inc.; John Gaudino, Array BioPharma, Inc.; Sashi Gopaul, Genentech, Inc.; Hoa Le, Genentech, Inc.; Xingrong Liu, Genentech, Inc.; Dan Sutherlin, Genentech, Inc.; Cyrus Khojasteh, Genentech, Inc. P339 Effect of Oral Administration of Antibiotics on the Pharmacokinetics of Hesperidin
Hye Hyun Yoo, Korea Institute of Science and Technology; Ming Ji Jin, Korea Institute of Science and Technology; Unyong Kim, Korea Institute of Science and Technology; Dong-Hyun Kim, Kyung-Hee University; Oh-Seung Kwon, Korea Institute of Science and Technology P362 The Intermolecular Disulfide Bonds of UGT1A Splice Products with Active UGT1A Enzymes May Determine their Ability to Inhibit Glucuronidation Activity
Mélanie Rouleau, Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University; Mario Harvey, Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University; Judith Bellemare, Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University; Chantal Guillemette, Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University P348 Kinetics of Bile Acid Sulfation by Human Sulfotransferase 2A1 (SULT2A1)
Yazen Alnouti, University of Nebraska Medical Center; Jiangeng Huang, University of Nebraska Medical Center; Sai Praneeth Bathena, University of Nebraska Medical Center P361 Significant Species Difference of Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
Lichuan Liu, Genentech; Jason Halladay, Genentech; Young Shin, Genentech; Susan Wong, Genentech; Melis Coraggio, Genentech; Hank La, Genentech; Matthew Baumgardner, Genentech; Hoa Le, Genentech; Peter Kuebler, Genentech; John C. Davis Jr., Genentech; X. Charlene Liao, Genentech; Joseph Lubach, Genentech; Alan Deese, Genentech; C. Gregory Sowell, Genentech; Kevin S. Currie, CGI Pharmaceuticals; Wendy B. Young, Genentech; Cyrus Khojasteh, Genentech; Cornelis Hop, Genentech; Harvey Wong, Genentech P360 Separation and Identification of Norcantharidin Metabolites in vivo
Wei Chunmin, Qilu Hospital of Shandong University P358 Quantification of Glutathione Adducts in Human Liver Microsomes using Ultra Performance Liquid Chromatography and Inductively Coupled Plasma Mass Spectrometry
Cathy MacDonald, AstraZeneca R&D Charnwood; Christopher Smith, AstraZeneca; Richard Weaver, AstraZeneca R&D Charnwood; Ian Wilson, AstraZeneca P351 Mechanism Studies for Determining the Loss of Nitrile Moiety and Formation of Primary Alcohol by CYP
Hoa Le, Genentech, Inc.; Susan Wong, Genentech, Inc.; Jim Driscoll, Genentech, Inc.; Cornelis Hop, Genentech, Inc.; Cyrus Khojasteh, Genentech, Inc. P336 Comparative Metabolism of T-2 Toxin by the Fractions of Hepatocytes from Rats, Pigs, Chickens and Carps
Zonghui Yuan, College of Veterinary Medicine,Huazhong Agricultural University; Qinghua Wu, Huazhong Agricultural University P343 Identification of Metabolites from Maropitant Using a Dual-Pressure Linear Ion Trap and Mass Frontier Software
Yingying Huang, Thermo Fisher Scientific; Rose Herbold, Thermo Fisher Scientific; David Nakamura, Thermo Fisher Scientific P345 In Vitro Hydrolysis and Trans-esterification of a Novel Ethyl Ester Prodrug, CDP323, in Human Liver and Intestinal Microsomes
Hugues Chanteux, UCB Pharma SA; Maria Rosa, UCB Pharma SA; Claude Delatour, UCB Pharma SA; Celine Jacques-Hespel, UCB Pharma SA; Steven Smith, UCB Pharma SA; Jean-Marie Nicolas, UCB Pharma SA P355 Polymorphisms of Flavin-Containing Monooxygenase 3 (FMO3) Gene in Healthy Turkish Population
Pinar Topal, Istanbul University; Gül Özhan, Istanbul University P338 Driving Efficiency in a High-throughput Metabolic Stability Assay Through a Generic High Resolution/Accurate Mass Method and Automated Data Processing
Yingying Huang, Thermo Fisher Scientific; Mark Sanders, Thermo Fisher Scientific; Wenqing (Angel) Shui, Thermo Fisher Scientific; Song Lin, Chiron Corp; Allen Zhang, Thermo Fisher Scientific; Caroline Ding, Thermo Fisher Scientific P352 Metabolic Activation of Strychnine to Reactive Intermediates by Human Liver Microsomes and CYP3A4
Yuxi Mao, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Zhong-Ze Fang, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Guang-Bo Ge, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Ling Yang, Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences P333 Characterization of Human UDP-Glucuronosyltransferases responsible for the in vitro Glucuronidation of Armillarisin A
Dongxue Sun, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University; Guang Bo Ge, Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Zhong-Ze Fang, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Liangliang Zhu, Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Ling Yang, Dalian Institute of Chemical Physics, Chinese Academy of Sciences P364 Ultra-performance liquid chromatographic–electrospray mass spectrometric determination (UPLC-ESI-MS) of hydroxylation metabolite of liquiritigenin in vitro: Assay development, human liver microsome activities and species differences
Ying Hu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Hui-Xin Liu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Ling Yang, Dalian Institute of Chemical Physics, Chinese Academy of Sciences P331 C5-Hydroxylation of Liquirtigenin Is Catalyzed Selectively by CYP1A2
Ying Hu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Hui-Xin Liu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Ling Yang, Dalian Institute of Chemical Physics, Chinese Academy of Sciences P334 Characterization of UGT Isoforms Involved in Liquiritigenin Glucuronidation in Human Liver Microsomes
Ying Hu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Hui-Xin Liu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Ling Yang, Dalian Institute of Chemical Physics, Chinese Academy of Sciences P335 Characterization of UGT Isoforms Involved in Naringenin Glucuronidation in Human Liver Microsomes
Ying Hu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Hui-Xin Liu, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Ling Yang, Dalian Institute of Chemical Physics, Chinese Academy of Sciences P332 Characterisation of major human metabolites of JM-1232(-) generated using microbial biotransformation techniques
Zbigniew R. Cybulski, Huntingdon Life Sciences Ltd; WenHao Zhu, Huntingdon Life Sciences Ltd; Brian John, Huntingdon Life Sciences; Takako Ohkura, Maruishi Pharmaceutical Co Ltd P353 MICROBIAL PRODUCTION of PHASE I and PHASE II METABOLITES of Propranolol
Cyrille Marvalin, Bertin-Pharma; Christine Soustelle, Bertin-Pharma; Robert Azerad, Université Paris Descartes - CNRS-UMR8601; Xavier Morge, Bertin-Pharma P363 Time Dependent Changes of Enzymatic Phase I and Phase II Activites In Plated Human Hepatocytes
Roberto Tolando, Celsis In Vitro Technologies; Scott Heyward, Celsis In Vitro Technologies; Micheal Chesebrough, Celsis In Vitro Technologies; Ji Young Lee, Celsis In Vitro Technologies; Timothy Moeller, Celsis In Vitro Technologies P340 Erythrocyte Folate LEVELS IN PATIENTS ON Hemodialysis
Saziye Sezin Palabiyik, Ataturk University, Faculty of Pharmacy; Gozde Girgin, Hacettepe University, Faculty of Pharmacy; Terken Baydar, Hacettepe University, Faculty of Pharmacy; Ramazan Cetinkaya, Faculty of Medicine, Ataturk University; Gonul Sahin, Hacettepe University, Faculty of Pharmacy P356 PRODUCTION of PHASE I and PHASE II METABOLITES of Diclofenac and Chlorzoxazone by Bioconversion USING NATURAL and Recombinant MICRO-Organisms
Christine Soustelle, Bertin-Pharma; Cyrille Marvalin, Bertin-Pharma; Robert Azerad, Université Paris Descartes - CNRS-UMR8601; Xavier Morge, Bertin-Pharma P342 Expressions of Hepatic Cytochrome P450 May be Regulated Dynamically and Cooperatively
Akihiro Hisaka, The University of Tokyo Hospital; Yu Sasaki, The University of Tokyo Hospital; Hiroshi Suzuki, The University of Tokyo Hospital |
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